(R,S)-Baclofen, GABAB agonist (ab120149)
Key features and details
- GABAB agonist
- CAS Number: 1134-47-0
- Soluble in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(R,S)-Baclofen, GABAB agonist -
Description
GABAB agonist -
Biological description
Selective GABAB receptor agonist. Antispasmodic.
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CAS Number
1134-47-0 -
Chemical structure
Properties
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Chemical name
(R,S)-4-Amino-3-(4-chlorophenyl)butanoic acid -
Molecular weight
213.66 -
Molecular formula
C10H12ClNO2 -
PubChem identifier
2284 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1 eq. NaOH to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(cc1)C(CN)CC(=O)O -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120149 has been referenced in 3 publications.
- Guo C et al. Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex. Elife 10:N/A (2021). PubMed: 34369877
- Copits BA et al. A photoswitchable GPCR-based opsin for presynaptic inhibition. Neuron 109:1791-1809.e11 (2021). PubMed: 33979635
- Sousa VC et al. Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of ?9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology 36:472-87 (2011). PubMed: 20927050