XAV939, Tankyrase inhibitor (ab120897)
Key features and details
- Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling.
- CAS Number: 284028-89-3
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
XAV939, Tankyrase inhibitor -
Description
Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling. -
Purity
> 98% -
CAS Number
284028-89-3 -
Chemical structure
Properties
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Chemical name
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one -
Molecular weight
312.31 -
Molecular formula
C14H11F3N2OS -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC1=NC(C2=CC=C(C(F)(F)F)C=C2)=NC3=C1CSCC3 -
Source
Synthetic
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Research areas
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab120897 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
Functional Studies |
Use at an assay dependent concentration.
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Notes |
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Functional Studies
Use at an assay dependent concentration. |
Images
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2D chemical structure image of ab120897, XAV939, Tankyrase inhibitor
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ab16051 staining ß-catenin in SW480 cells treated with XAV939 (ab120897), by ICC/IF. Increase of ß-catenin cytoplasmic expression and decrease in nuclear expression correlates with increased concentration of XAV939, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120897 (XAV939) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16051 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab120897 has been referenced in 8 publications.
- Häfliger J et al. Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity. Cell Mol Gastroenterol Hepatol 15:717-739 (2023). PubMed: 36516930
- Iwatsuki K et al. Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells. Cell Rep Methods 3:100542 (2023). PubMed: 37671016
- Cheng B et al. Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin. Tissue Eng Regen Med 19:823-837 (2022). PubMed: 35467329
- Polley A et al. Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro. Int J Cell Biol 2020:2045969 (2020). PubMed: 32328102
- Du B et al. Long non-coding RNA MALAT1 suppresses the proliferation and migration of endothelial progenitor cells in deep vein thrombosis by regulating the Wnt/ß-catenin pathway. Exp Ther Med 20:3138-3146 (2020). PubMed: 32855682
- Hamidi S et al. Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation. Development 147:N/A (2020). PubMed: 32014865
- Fagnocchi L et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun 7:11903 (2016). PubMed: 27301576
- Lafon-Hughes L et al. VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt. PeerJ 2:e617 (2014). PubMed: 25332845