GTP-gamma-S, G-protein-activating GTP analog (ab146662)
Key features and details
- G-protein-activating GTP analog
- CAS Number: 94825-44-2
- Purity: > 90%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GTP-gamma-S, G-protein-activating GTP analog -
Description
G-protein-activating GTP analog -
Purity
> 90% -
CAS Number
94825-44-2 -
Chemical structure
Properties
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Molecular weight
539.24 -
Molecular formula
C10H16N5O13P3S -
PubChem identifier
135445735 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N=C(NC2=O)N -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab146662 has been referenced in 4 publications.
- Ahn D et al. Gαs slow conformational transition upon GTP binding and a novel Gαs regulator. iScience 26:106603 (2023). PubMed: 37128611
- Kutsch M et al. Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions. EMBO J 39:e104926 (2020). PubMed: 32510692
- Wandel MP et al. Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nat Immunol 21:880-891 (2020). PubMed: 32541830
- Kovalski JR et al. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Mol Cell 73:830-844.e12 (2019). PubMed: 30639242