Recombinant Anti-BAFF-R antibody [EPR10914] (ab168389)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10914] to BAFF-R
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
Related conjugates and formulations
Overview
-
Product name
Anti-BAFF-R antibody [EPR10914]
See all BAFF-R primary antibodies -
Description
Rabbit monoclonal [EPR10914] to BAFF-R -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IFmore details
Unsuitable for: Flow Cyt,IP or WB -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human BAFF-R.
-
Positive control
- Human colon and tonsil tissues; Raji cells.
-
General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading...
-
Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EPR10914 -
Isotype
IgG -
Research areas
Associated products
-
Alternative Versions
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab168389 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
1/250 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
|
|
ICC/IF |
1/50 - 1/100.
|
Notes |
---|
IHC-P
1/250 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
ICC/IF
1/50 - 1/100. |
Target
-
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. -
Tissue specificity
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. -
Involvement in disease
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
Sequence similarities
Contains 1 TNFR-Cys repeat. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 115650 Human
- Omim: 606269 Human
- SwissProt: Q96RJ3 Human
- Unigene: 344088 Human
-
Alternative names
- B cell activating factor receptor antibody
- B-cell-activating factor receptor antibody
- BAFF R antibody
see all
Images
-
Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling BAFF-R with ab168389 at 1/250 dilution.
Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
-
Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling BAFF-R with ab168389 at 1/250 dilution.
Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
-
Immunofluorescent analysis of Raji cells labeling BAFF-R with ab168389 at 1/50 dilution.
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab168389 has not yet been referenced specifically in any publications.