Recombinant Anti-SIGIRR antibody [EPR12638] (ab177937)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR12638] to SIGIRR
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Related conjugates and formulations
Overview
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Product name
Anti-SIGIRR antibody [EPR12638]
See all SIGIRR primary antibodies -
Description
Rabbit monoclonal [EPR12638] to SIGIRR -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide within Human SIGIRR aa 1-100 (Cysteine residue). The exact sequence is proprietary.
Database link: Q6IA17 -
Positive control
- Fetal kidney lysate.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR12638 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab177937 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 46 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 46 kDa. |
Target
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Function
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. -
Tissue specificity
Mainly expressed in epithelial tissues such as kidney, lung and gut. -
Sequence similarities
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 59307 Human
- Entrez Gene: 24058 Mouse
- Entrez Gene: 309106 Rat
- Omim: 605478 Human
- SwissProt: Q6IA17 Human
- SwissProt: Q9JLZ8 Mouse
- SwissProt: Q4V892 Rat
- Unigene: 501624 Human
see all -
Alternative names
- Ig IL1 related receptor antibody
- MGC110992 antibody
- SIGIR_HUMAN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab177937 has been referenced in 1 publication.
- Gao T et al. Platelet-activating factor induces the stemness of ovarian cancer cells via the PAF/PAFR signaling pathway. Am J Transl Res 12:7249-7261 (2020). PubMed: 33312364