anti-Golimumab ELISA Kit (ab237662)
Key features and details
- Sample type: Plasma, Serum
- Detection method: Colorimetric
- Assay type: Sandwich (qualitative)
- Reacts with: Human
Overview
-
Product name
anti-Golimumab ELISA Kit
See all Golimumab kits -
Detection method
Colorimetric -
Sample type
Serum, Plasma -
Assay type
Sandwich (qualitative) -
Assay duration
Multiple steps standard assay -
Species reactivity
Reacts with: Human -
Product overview
anti-Golimumab ELISA Kit (ab237662) is designed to quantify/measure the antibody against Golimumab with high specificity and sensitivity in biological matrices.
-
Notes
This product is manufactured by BioVision, an Abcam company and was previously called E4393 BioSim™ anti-Golimumab (Simponi®) (Human) ELISA Kit. E4393-100 is the same size as the 96 test size of ab237662.
-
Platform
Microplate
Properties
-
Storage instructions
Store at +4°C. Please refer to protocols. -
Components 1 x 96 tests Micro ELISA Plate 1 unit Positive Control 1 x 0.25ml Negative Control 1 x 0.5ml Assay Buffer 1 x 12ml Peroxidase Conjugate 1 x 12ml TMB substrate 1 x 12ml Stop Solution 1 x 12ml Wash buffer (20X) 1 x 50ml Plate sealers 1 unit -
Relevance
Golimumab (Simponi®) is a human immunoglobulin G1? monoclonal antibody which is specific for pro-inflammatory cytokine, tumor necrosis factor-a (TNFa). In 2009, it was approved by FDA for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis in adult patients. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis, including juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis patients and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased levels of TNF are also found in psoriasis (Ps) plaques. Golimumab binds to both the soluble and transmembrane bioactive forms of human TNF and prevent TNF from binding to its receptors and finally inhibits biological activity of TNF. -
Alternative names
- Simponi
- tumor necrosis factor-a
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab237662 has not yet been referenced specifically in any publications.