Anti-Bile Acid Receptor NR1H4 antibody (ab28480)
Key features and details
- Rabbit polyclonal to Bile Acid Receptor NR1H4
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-Bile Acid Receptor NR1H4 antibody
See all Bile Acid Receptor NR1H4 primary antibodies -
Description
Rabbit polyclonal to Bile Acid Receptor NR1H4 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Human -
Immunogen
Synthetic peptide:
R(224)KNVKQHADQTVNED(238)
, corresponding to amino acids 224/238 of Mouse FXR (Peptide available as ab39820.) -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab28480 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500. Predicted molecular weight: 56 kDa.
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Notes |
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WB
1/500. Predicted molecular weight: 56 kDa. |
Target
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Function
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. -
Sequence similarities
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 9971 Human
- Entrez Gene: 20186 Mouse
- Entrez Gene: 60351 Rat
- Omim: 603826 Human
- SwissProt: Q96RI1 Human
- SwissProt: Q60641 Mouse
- SwissProt: Q62735 Rat
- Unigene: 282735 Human
see all -
Alternative names
- BAR antibody
- Bile acid receptor antibody
- Farnesoid X activated receptor antibody
see all
Datasheets and documents
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Datasheet download
References (7)
ab28480 has been referenced in 7 publications.
- Wang L et al. Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11-deficient mice. J Pathol 255:412-424 (2021). PubMed: 34410012
- Zhang S et al. Rosiglitazone alleviates intrahepatic cholestasis induced by a-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-?12,14 -PGJ2 and Nogo. Br J Pharmacol 177:1041-1060 (2020). PubMed: 31658492
- Li M et al. The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines. Cell Death Dis 11:31 (2020). PubMed: 31949131
- Wei M et al. A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility. EBioMedicine 55:102766 (2020). PubMed: 32408110
- Huang F et al. Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism. Nat Commun 10:4971 (2019). PubMed: 31672964
- Xia Y et al. Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction. Cardiovasc Res 114:1335-1349 (2018). PubMed: 29668847
- Liu L et al. Hepatic Tmem30a Deficiency Causes Intrahepatic Cholestasis by Impairing Expression and Localization of Bile Salt Transporters. Am J Pathol 187:2775-2787 (2017). PubMed: 28919113