AMMC iodide (ab285378)
Key features and details
- Human cytochrome P450 CYP2D6 isozyme substrate
- CAS Number: 256234-27-2
- Purity: > 98%
Acetonitrile
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AMMC iodide -
Description
Human cytochrome P450 CYP2D6 isozyme substrate -
Biological description
AMMC iodide is a useful substrate for the human cytochrome P450 CYP2D6 isozyme. It is demethylated to the fluorescent product 3-[2-(N,N-diethyl-N-methyl ammonium)ethyl]-7-hydroxy-4-methylcoumarin (AMHC). After the AMMC is hydrolyzed, the pH is increased by addition of base for optimal fluorescence detection. AMMC has been used with human liver microsomes to determine CYP2D6 activity and inhibition.
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Purity
> 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 2873 AMMC iodide. 2873-5 is the same size as the 5 mg size of ab285378.
Protect from air and light.
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CAS Number
256234-27-2
Properties
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Chemical name
diethyl-[2-(7-methoxy-4-methyl-2-oxochromen-3-yl)ethyl]-methylazanium;iodide
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Molecular weight
431.30 -
Molecular formula
C18H26INO3 -
PubChem identifier
15487105 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Acetonitrile
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[N+](C)(CC)CCC1=C(C2=C(C=C(C=C2)OC)OC1=O)C.[I-] -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab285378 has not yet been referenced specifically in any publications.