GSK-2982772 (ab286962)
Key features and details
- A potent and ATP-competitive receptor-interacting protein-1 (RIP1) kinase inhibitor
- CAS Number: 1622848-92-3
- Purity: >= 98%
Soluble in DMSO
- Form / State: Solid
Overview
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Product name
GSK-2982772 -
Description
A potent and ATP-competitive receptor-interacting protein-1 (RIP1) kinase inhibitor -
Alternative names
- UNII-T5W3M0VO9B
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Biological description
A potent and ATP-competitive receptor-interacting protein-1 (RIP1) kinase inhibitor (IC50 = 1 nM).
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Purity
>= 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called B2232 GSK-2982772. B2232-5 is the same size as the 5 mg size of ab286962.
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CAS Number
1622848-92-3
Properties
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Chemical name
5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide
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Molecular weight
377.40 -
Molecular formula
C20H19N5O3 -
PubChem identifier
77108121 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in DMSO
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C2=CC=CC=C2OC[C@@H](C1=O)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4 -
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab286962 has been referenced in 1 publication.
- Harris PA et al. Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem 60:1247-1261 (2017). PubMed: 28151659