CHZ868 (ab287065)
Key features and details
- potent, selective type II JAK2 inhibitor
- CAS Number: 1895895-38-1
- Purity: >= 98%
>100 mg/ml DMSO
- Form / State: Solid
Overview
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Product name
CHZ868 -
Description
potent, selective type II JAK2 inhibitor -
Biological description
CHZ868 is a potent and selective type II JAK2 inhibitor (IC50 = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.
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Purity
>= 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called B2475 CHZ868. B2475-5 is the same size as the 5 mg size of ab287065.
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CAS Number
1895895-38-1
Properties
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Chemical name
N-[4-[2-(2,4-difluoroanilino)-1,4-dimethylbenzimidazol-5-yl]oxypyridin-2-yl]acetamide
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Molecular weight
423.42 -
Molecular formula
C22H19F2N5O2 -
PubChem identifier
91885989 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
>100 mg/ml DMSO
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SMILES
CC1=C(C=CC2=C1N=C(N2C)NC3=C(C=C(C=C3)F)F)OC4=CC(=NC=C4)NC(=O)C -
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab287065 has not yet been referenced specifically in any publications.