ML-385 (ab287109)
Key features and details
- A potent and selective NRF2 inhibitor
- CAS Number: 846557-71-9
- Purity: >= 98%
>25 mg/ml in DMSO
- Form / State: Solid
Overview
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Product name
ML-385 -
Description
A potent and selective NRF2 inhibitor -
Alternative names
- N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
- SMR000173724
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Biological description
A potent and selective Nrf2 inhibitor (Nrf2; IC50 = 1.9 µM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.
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Purity
>= 98% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called B2605 ML-385. B2605-25 is the same size as the 25 mg size of ab287109.
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CAS Number
846557-71-9
Properties
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Chemical name
2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
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Molecular weight
511.59 -
Molecular formula
C29H25N3O4S -
PubChem identifier
1383822 -
Storage instructions
Shipped at 4°C. Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. -
Solubility overview
>25 mg/ml in DMSO
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab287109 has been referenced in 1 publication.
- Singh A et al. Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. ACS Chem Biol 11:3214-3225 (2016). PubMed: 27552339