Human Glucocorticoid Receptor alpha peptide (ab39764)
Key features and details
- Purity: > 90% SDS-PAGE
- Suitable for: Neutralising, Blocking
Description
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Product name
Human Glucocorticoid Receptor alpha peptide -
Purity
> 90 % SDS-PAGE. -
Animal free
No -
Nature
Synthetic -
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Species
Human -
Sequence
CEIITNQIPKYSNGNIKK -
Amino acids
755 to 771
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Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab39764 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Neutralising
Blocking - Blocking peptide for Anti-Glucocorticoid Receptor alpha antibody (ab3580)
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
Double distilled water.
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ReconstitutionReconstitute with 0.1ml distilled water for a 0.5mg/ml solution.
General Info
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Alternative names
- GCCR
- GCR
- Glucocorticoid receptor
see all -
Relevance
Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the Glucocorticoid Receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform translocates from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR alpha has a greater affinity for GR response elements (GREs) than GR beta only when in the ligand bound state. -
Cellular localization
Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand; nuclear after ligand-binding.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab39764 has not yet been referenced specifically in any publications.