Anti-Interferon gamma antibody [B-B1] - BSA and Azide free (ab47343)
Key features and details
- Mouse monoclonal [B-B1] to Interferon gamma - BSA and Azide free
- Suitable for: Blocking, Flow Cyt
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-Interferon gamma antibody [B-B1] - BSA and Azide free
See all Interferon gamma primary antibodies -
Description
Mouse monoclonal [B-B1] to Interferon gamma - BSA and Azide free -
Host species
Mouse -
Specificity
ab47343 recognises both natural and recombinant Human Interferon gamma.
It inhibits Interferon gamma induced proliferation.
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Tested applications
Suitable for: Blocking, Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length Human Interferon gamma.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Constituent: 100% PBS
Sterile-filtered through 0.22 µm. Carrier and preservative free -
Carrier free
Yes -
Concentration information loading...
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Purity
Ion Exchange Chromatography -
Purification notes
Sterile filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free. -
Clonality
Monoclonal -
Clone number
B-B1 -
Myeloma
x63-Ag8.653 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab47343 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Blocking |
Use at an assay dependent concentration.
ab47343 blocks Interferon gamma-induced proliferation. |
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Flow Cyt |
Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Notes |
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Blocking
Use at an assay dependent concentration. ab47343 blocks Interferon gamma-induced proliferation. |
Flow Cyt
Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Target
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Function
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. -
Tissue specificity
Released primarily from activated T lymphocytes. -
Involvement in disease
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis. -
Sequence similarities
Belongs to the type II (or gamma) interferon family. -
Post-translational
modificationsProteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 3458 Human
- Omim: 147570 Human
- SwissProt: P01579 Human
- Unigene: 856 Human
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Alternative names
- IF 1 antibody
- IFG antibody
- IFI antibody
see all
Images
Datasheets and documents
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Datasheet download
References (0)
ab47343 has not yet been referenced specifically in any publications.