Anti-Cardiac Troponin I antibody [19C7] (ab92408)
Key features and details
- Mouse monoclonal [19C7] to Cardiac Troponin I
- Suitable for: WB, Sandwich ELISA
- Reacts with: Human
- Isotype: IgG2b
Overview
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Product name
Anti-Cardiac Troponin I antibody [19C7]
See all Cardiac Troponin I primary antibodies -
Description
Mouse monoclonal [19C7] to Cardiac Troponin I -
Host species
Mouse -
Specificity
No cross-reaction with skeletal muscle Troponin I -
Tested applications
Suitable for: WB, Sandwich ELISAmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chicken, Xenopus laevis -
Immunogen
Synthetic peptide:
ISASRKLQL
, corresponding to amino acids 41-49 of Human Cardiac Troponin I -
Epitope
Recognises an epitope included within aa 41-49 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
19C7 -
Myeloma
Sp2/0 -
Isotype
IgG2b -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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sELISA pair antibody
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab92408 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use at an assay dependent concentration.
|
|
Sandwich ELISA |
Use at an assay dependent concentration. Can be paired for Sandwich ELISA with HRP Mouse monoclonal [16A11] to Cardiac Troponin I (ab24460).
Recommended pairs for quantitative sandwich immunoassay (capture-detection):ab92408 - ab24460. |
Notes |
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WB
Use at an assay dependent concentration. |
Sandwich ELISA
Use at an assay dependent concentration. Can be paired for Sandwich ELISA with HRP Mouse monoclonal [16A11] to Cardiac Troponin I (ab24460). Recommended pairs for quantitative sandwich immunoassay (capture-detection):ab92408 - ab24460. |
Target
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Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. -
Involvement in disease
Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. -
Sequence similarities
Belongs to the troponin I family. - Information by UniProt
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Database links
- Entrez Gene: 7137 Human
- Entrez Gene: 397803 Xenopus laevis
- Omim: 191044 Human
- SwissProt: P19429 Human
- SwissProt: P50754 Xenopus laevis
- Unigene: 709179 Human
- Unigene: 935 Xenopus laevis
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Alternative names
- cardiac muscle antibody
- Cardiac troponin I antibody
- cardiomyopathy, dilated 2A (autosomal recessive) antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab92408 has been referenced in 6 publications.
- Zhang ZY et al. Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway. PLoS One 17:e0273542 (2022). PubMed: 36001597
- Liang F et al. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. Elife 10:N/A (2021). PubMed: 34099102
- Cui YX et al. A new methodological sequence to expand and transdifferentiate human umbilical cord blood derived CD133+ cells into a cardiomyocyte-like phenotype. Stem Cell Rev 9:350-9 (2013). PubMed: 21948151
- Clause KC et al. Developing cardiac and skeletal muscle share fast-skeletal myosin heavy chain and cardiac troponin-I expression. PLoS One 7:e40725 (2012). WB, IHC (PFA fixed) . PubMed: 22808244
- Laflamme MA et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 25:1015-24 (2007). PubMed: 17721512
- Banz Y et al. Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1. Cardiovasc Res 76:482-93 (2007). PubMed: 17825275