Overview

  • Product name

    Abamectin, GABA-mimetic antihelmintic agent
  • Description

    Potent GABA-mimetic antihelmintic agent
  • Biological description

    Potent GABA-mimetic antihelmintic agent. Mixture of avermectin B1a and avermectin B1b (80:20 ratio). Shows GABA-mimetic effects in vivo similar to related macrocyclic lactone Ivermectin (ab141813). Inhibits adenine nucleotide translocator and FoF1-ATPase. Inhibits mitochrondrial activity and reduces cellular respiration.
  • Purity

    > 70%
  • CAS Number

    71751-41-2
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    873.08
  • Molecular formula

    C48H72O14 (for Avermectin B1a, R=CH2CH3)
  • PubChem identifier

    44350503
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(C)C1C(C=CC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Maioli MA  et al. The role of mitochondria and biotransformation in abamectin-induced cytotoxicity in isolated rat hepatocytes. Toxicol In Vitro 27:570-9 (2013). Read more (PubMed: 23142325) »
  • Yang CC Acute human toxicity of macrocyclic lactones. Curr Pharm Biotechnol 13:999-1003 (2012). Read more (PubMed: 22039794) »
  • Molinari G  et al. New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, abamectin and ivermectin. Cytogenet Genome Res 128:37-45 (2010). Read more (PubMed: 20389039) »
  • Diao X  et al. Toxicity of the anthelmintic abamectin to four species of soil invertebrates. Environ Pollut 148:514-9 (2007). Read more (PubMed: 17258847) »

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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