Overview

  • Product name

  • Description

    Rabbit polyclonal to ABAT/GABA-T
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment within Human ABAT/GABA-T aa 1-245. The exact sequence is proprietary.

  • Positive control

    • SK-N-SH, Mouse brain and Rat brain whole cell lysates; HepG2 cells; U373 xenograft.
  • General notes

    Previously labelled as ABAT. 

Properties

Applications

Our Abpromise guarantee covers the use of ab152134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 56 kDa.
IHC-P 1/100 - 1/1000.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
  • Tissue specificity

    Liver > pancreas > brain > kidney > heart > placenta.
  • Involvement in disease

    Defects in ABAT are a cause of gamma-aminobutyrate transaminase deficiency (GABA-AT deficiency) [MIM:613163]. The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.
  • Sequence similarities

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • (S) 3 amino 2 methylpropionate transaminase antibody
    • (S)-3-amino-2-methylpropionate transaminase antibody
    • 4 aminobutyrate aminotransferase antibody
    • 4 aminobutyrate aminotransferase, mitochondrial antibody
    • 4-aminobutyrate aminotransferase antibody
    • ABAT antibody
    • FLJ17813 antibody
    • FLJ30272 antibody
    • GABA aminotransferase antibody
    • GABA AT antibody
    • GABA T antibody
    • GABA transaminase antibody
    • GABA transferase antibody
    • GABA-AT antibody
    • GABA-T antibody
    • GABAT antibody
    • GABT_HUMAN antibody
    • Gamma amino N butyrate transaminase antibody
    • Gamma-amino-N-butyrate transaminase antibody
    • hCG1984265 antibody
    • L AIBAT antibody
    • L-AIBAT antibody
    • LAIBAT antibody
    • mitochondrial antibody
    • NPD009 antibody
    see all

Images

  • Anti-ABAT/GABA-T antibody (ab152134) at 1/5000 dilution + Mouse brain whole cell lysate at 20 µg

    Predicted band size: 56 kDa



    7.5% SDS PAGE
  • Anti-ABAT/GABA-T antibody (ab152134) at 1/1000 dilution + Rat brain whole cell lysate at 50 µg

    Predicted band size: 56 kDa



    7.5% SDS PAGE
  • Anti-ABAT/GABA-T antibody (ab152134) at 1/1000 dilution + SK-N-SH whole cell lysate at 30 µg

    Predicted band size: 56 kDa



    7.5% SDS PAGE
  • Immunofluorescent analysis of methanol-fixed HepG2 cells labeling ABAT/GABA-T with ab152134 at 1/500 dilution. Lower panel co-stained with Hoechst 33342.

  • Immunohistochemical analysis of paraffin-embedded U373 xenograft labeling ABAT/GABA-T with ab152134 at 1/500 dilution.

References

This product has been referenced in:

  • Huo Q  et al. Prefrontal Cortical GABAergic Dysfunction Contributes to Aberrant UP-State Duration in APP Knockout Mice. Cereb Cortex : (2016). Read more (PubMed: 27552836) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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