Anti-ABCA1 antibody [AB.H10] (ab18180)

Knockout Tested Mouse monoclonal ABCA1 antibody [AB.H10]. Validated in WB, ELISA, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Chicken, Cow, Human. Cited in 81 publication(s).

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ab18180 has been referenced in 83 publications.

  • Huang Z  et al. G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. FASEB J 33:1631-1643 (2019). PubMed: 30153049
  • Fan J  et al. CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REG?. Nat Commun 10:425 (2019). PubMed: 30683852
  • O'Neill S  et al. miR-758-3p: a blood-based biomarker that's influence on the expression of CERP/ABCA1 may contribute to the progression of obesity to metabolic syndrome. Oncotarget 9:9379-9390 (2018). PubMed: 29507696
  • Mukwaya A  et al. Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization. Angiogenesis 21:395-413 (2018). IHC-P ; Rat . PubMed: 29445990
  • Wen G  et al. Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis. J Am Heart Assoc 7:N/A (2018). PubMed: 29437605
  • Wang J  et al. Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells. Vet Immunol Immunopathol 197:87-92 (2018). PubMed: 29475512
  • Zhang X  et al. Human Gingiva-Derived Mesenchymal Stem Cells Modulate Monocytes/Macrophages and Alleviate Atherosclerosis. Front Immunol 9:878 (2018). PubMed: 29760701
  • Zhao ZW  et al. Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway. Biochim Biophys Acta 1863:806-822 (2018). ICC/IF . PubMed: 29678642
  • Oldoni F  et al. Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans. Arterioscler Thromb Vasc Biol 38:1440-1453 (2018). PubMed: 29853565
  • Zhou CC  et al. Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain. Toxicol Lett 296:173-183 (2018). PubMed: 29908845
  • Zhang G  et al. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicol Lett 296:31-38 (2018). PubMed: 30036686
  • Dumas SN & Ntambi JM Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice. PLoS One 13:e0199682 (2018). PubMed: 29965978
  • Xie C  et al. Gene expression profiles of HTR8-S/Vneo cells after changes in ABCA1 expression. Funct Integr Genomics N/A:N/A (2018). PubMed: 29931611
  • Tumurkhuu G  et al. Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1ß Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab 28:432-448.e4 (2018). PubMed: 29937375
  • Canfrán-Duque A  et al. Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Mol Med 9:1244-1262 (2017). WB ; Mouse . PubMed: 28674080
  • Berger CN  et al. Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo. Cell Metab 26:738-752.e6 (2017). WB . PubMed: 28988824
  • Liu Q  et al. C1q/TNF-related protein 9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating AMP-dependent kinase. J Cell Mol Med 21:2823-2836 (2017). Human . PubMed: 28524645
  • Ikhlef S  et al. Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport. PLoS One 12:e0173385 (2017). WB ; Mouse . PubMed: 28278274
  • Cheng-Mao X  et al. Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries. Biomed Res Int 2017:8248094 (2017). WB, IHC, RT-PCR ; Human . PubMed: 28630870
  • Wang L  et al. Effect of rosiglitazone on amyloid precursor protein processing and Aß clearance in streptozotocin-induced rat model of Alzheimer's disease. Iran J Basic Med Sci 20:474-480 (2017). WB ; Rat . PubMed: 28656081
  • Nam KN  et al. Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice. Sci Rep 7:4307 (2017). WB . PubMed: 28655926
  • Fu Y  et al. Tribbles homolog 1 enhances cholesterol efflux from oxidized low-density lipoprotein-loaded THP-1 macrophages. Exp Ther Med 14:862-866 (2017). PubMed: 28673011
  • Liao H  et al. Intermedin Ameliorates Atherosclerosis by Increasing Cholesterol Efflux Through the cAMP-PKA Pathway in Macrophage RAW264.7 Cell Line. Med Sci Monit 23:5462-5471 (2017). PubMed: 29146892
  • Hammer SS  et al. The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor. EBioMedicine 22:181-190 (2017). PubMed: 28774737
  • Vienken H  et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep 7:43575 (2017). WB . PubMed: 28262793
  • Sithu SD  et al. Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats. JCI Insight 2:N/A (2017). WB ; Rat . PubMed: 28469073
  • Na TY  et al. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep 7:43823 (2017). WB ; Human . PubMed: 28266648
  • Yang DS  et al. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice. Hum Mol Genet 26:843-859 (2017). PubMed: 28062666
  • Wu BJ  et al. Reduction of In-Stent Restenosis by Cholesteryl Ester Transfer Protein Inhibition. Arterioscler Thromb Vasc Biol 37:2333-2341 (2017). PubMed: 29025709
  • Zhang X  et al. Oncostatin M receptor ß deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. J Lipid Res 58:895-906 (2017). PubMed: 28258089
  • Aryal B  et al. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun 7:12313 (2016). ICC/IF ; Mouse . PubMed: 27460411
  • Lee KI  et al. Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease. J Neuroinflammation 13:92 (2016). PubMed: 27121378
  • Gui YZ  et al. Betulin attenuates atherosclerosis in apoE(-/-) mice by up-regulating ABCA1 and ABCG1. Acta Pharmacol Sin 37:1337-1348 (2016). PubMed: 27374487
  • Scharinger B  et al. Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice. J Mol Cell Cardiol 99:35-46 (2016). PubMed: 27497529
  • Zhao JF  et al. Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation. Int J Biol Sci 12:812-23 (2016). PubMed: 27313495
  • Kimura T  et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun 7:13130 (2016). WB . PubMed: 27731330
  • Zhang BC  et al. Luteolin Attenuates Foam Cell Formation and Apoptosis in Ox-LDL-Stimulated Macrophages by Enhancing Autophagy. Cell Physiol Biochem 39:2065-2076 (2016). PubMed: 27825167
  • Pedigo CE  et al. Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury. J Clin Invest 126:3336-50 (2016). PubMed: 27482889
  • Goedeke L  et al. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat Med 21:1280-9 (2015). PubMed: 26437365
  • Goedeke L  et al. miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice. Atherosclerosis 243:499-509 (2015). PubMed: 26520906
  • Lin YW  et al. RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages. J Mol Cell Cardiol 79:287-94 (2015). WB ; Mouse . PubMed: 25528964
  • Zhao X  et al. Perilipin1 deficiency in whole body or bone marrow-derived cells attenuates lesions in atherosclerosis-prone mice. PLoS One 10:e0123738 (2015). Mouse . PubMed: 25855981
  • Wagschal A  et al. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med 21:1290-7 (2015). PubMed: 26501192
  • Zhong CY  et al. Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep 5:10512 (2015). WB ; Mouse . PubMed: 26015368
  • Gillespie MA  et al. An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux. EMBO J 34:1244-58 (2015). IP ; Mouse . PubMed: 25755249
  • Singh NK  et al. Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nat Commun 6:7450 (2015). PubMed: 26104863
  • Szántó M  et al. Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels. Biochim Biophys Acta 1842:594-602 (2014). Mouse . PubMed: 24365238
  • Röhrl C  et al. Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells. J Lipid Res 55:94-103 (2014). WB . PubMed: 24179149
  • Zhao J  et al. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem 289:11282-92 (2014). WB ; Human . PubMed: 24599963
  • Pedrelli M  et al. Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice. PLoS One 9:e93552 (2014). WB ; Mouse . PubMed: 24695360
  • Goedeke L  et al. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med 6:1133-41 (2014). WB ; Mouse . PubMed: 25038053
  • Saeed AA  et al. Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain. J Biol Chem 289:23712-22 (2014). WB ; Mouse . PubMed: 24973215
  • Nagajyothi F  et al. High fat diet modulates Trypanosoma cruzi infection associated myocarditis. PLoS Negl Trop Dis 8:e3118 (2014). WB ; Mouse . PubMed: 25275627
  • Ramírez CM  et al. RNA binding protein HuR regulates the expression of ABCA1. J Lipid Res 55:1066-76 (2014). PubMed: 24729624
  • Sorrenson B  et al. Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate. J Lipid Res 54:55-62 (2013). PubMed: 23087442
  • Jones RJ  et al. The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1. J Pharmacol Exp Ther 346:381-92 (2013). PubMed: 23820125
  • Baselga-Escudero L  et al. Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. Nucleic Acids Res N/A:N/A (2013). WB ; Human . PubMed: 24165878
  • Nicod N & Parker RS Vitamin E secretion by Caco-2 monolayers to APOA1, but not to HDL, is vitamer selective. J Nutr 143:1565-72 (2013). PubMed: 23946344
  • Rottiers V  et al. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Sci Transl Med 5:212ra162 (2013). WB . PubMed: 24259050
  • Zhang X  et al. Cholesterol metabolite, 5-cholesten-3ß-25-diol-3-sulfate, promotes hepatic proliferation in mice. J Steroid Biochem Mol Biol 132:262-70 (2012). WB ; Mouse . PubMed: 22732306
  • Vaisman BL  et al. Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis. J Lipid Res 53:158-67 (2012). WB . PubMed: 22039582
  • Kim J  et al. MiR-106b impairs cholesterol efflux and increases Aß levels by repressing ABCA1 expression. Exp Neurol 235:476-83 (2012). PubMed: 22119192
  • Yamamoto S  et al. Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport. Circulation 124:1382-90 (2011). PubMed: 21859969
  • Boone LR  et al. Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter. Atherosclerosis 218:77-82 (2011). PubMed: 21605865
  • Liu D  et al. Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1. Am J Physiol Cell Physiol 301:C739-48 (2011). PubMed: 21734188
  • Bhattacharjee J  et al. Expression and localization of ATP binding cassette transporter A1 (ABCA1) in first trimester and term human placenta. Placenta 31:423-30 (2010). PubMed: 20338636
  • Schimanski S  et al. Expression of the lipid transporters ABCA3 and ABCA1 is diminished in human breast cancer tissue. Horm Metab Res 42:102-9 (2010). IHC-P ; Human . PubMed: 19902402
  • Civelek M  et al. Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo. Am J Physiol Heart Circ Physiol 298:H163-70 (2010). PubMed: 19897713
  • Suon S  et al. Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-ß peptides in the cerebral spinal fluid of rats. Mol Neurodegener 5:44 (2010). WB . PubMed: 21034469
  • Rohrer L  et al. High-density lipoprotein transport through aortic endothelial cells involves scavenger receptor BI and ATP-binding cassette transporter G1. Circ Res 104:1142-50 (2009). PubMed: 19372466
  • Hu YW  et al. Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells. Atherosclerosis 204:e35-43 (2009). PubMed: 19070858
  • Lagor WR  et al. Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. Arterioscler Thromb Vasc Biol 29:40-6 (2009). WB ; Mouse . PubMed: 19008531
  • Lee TS  et al. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci 84:97-104 (2009). WB ; Rat . PubMed: 19041881
  • Mauerer R  et al. High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages. Exp Mol Med 41:126-32 (2009). WB ; Human . PubMed: 19287193
  • Jiang LS  et al. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. Cardiovasc Res 81:805-13 (2009). PubMed: 19074161
  • Kobayashi N  et al. Characterization of the ATP-dependent Sphingosine 1-Phosphate Transporter in Rat Erythrocytes. J Biol Chem 284:21192-200 (2009). WB ; Human, Rat . PubMed: 19531471
  • Poitou C  et al. Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux. J Clin Endocrinol Metab 94:1810-7 (2009). PubMed: 19223523
  • Sacchetti P  et al. Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell 5:409-19 (2009). IHC (PFA fixed) ; Mouse . PubMed: 19796621
  • Lin YC  et al. ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells. Biochem Biophys Res Commun 382:189-95 (2009). WB, ICC/IF ; Rat . PubMed: 19275878
  • Li T  et al. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res 48:373-84 (2007). PubMed: 17088262
  • Miakotina OL  et al. Human adenovirus modulates surfactant phospholipid trafficking. Traffic 8:1765-77 (2007). PubMed: 17897321
  • Cavelier C  et al. ATP-Binding cassette transporter A1 modulates apolipoprotein A-I transcytosis through aortic endothelial cells. Circ Res 99:1060-6 (2006). WB . PubMed: 17053191
  • Jiang YJ  et al. Regulation of ABCA1 expression in human keratinocytes and murine epidermis. J Lipid Res 47:2248-58 (2006). PubMed: 16825673

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