Overview

  • Product name

    Anti-ABCB6/PRP antibody - C-terminal
    See all ABCB6/PRP primary antibodies
  • Description

    Rabbit polyclonal to ABCB6/PRP - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human ABCB6/PRP aa 786-842 (C terminal).
    Sequence:

    STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDT KPQTMER


    Database link: Q9NP58

  • Positive control

    • IHC-P: Human testis tissue. ICC/IF: U-251 MG cells.
  • General notes

     This product was previously labelled as ABCB6

     

Properties

Applications

Our Abpromise guarantee covers the use of ab224575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function

    Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
  • Tissue specificity

    Widely expressed. Highest expression in heart and skeletal muscles.
  • Sequence similarities

    Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 1 ABC transporter domain.
  • Developmental stage

    Highly expressed in fetal liver.
  • Cellular localization

    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ABC antibody
    • ABC transporter umat antibody
    • ABC14 antibody
    • Abcb6 antibody
    • ABCB6_HUMAN antibody
    • ATP binding cassette sub family B member 6, mitochondrial precursor antibody
    • ATP binding cassette, sub family B (MDR/TAP), member 6 antibody
    • ATP-binding cassette half-transporter antibody
    • ATP-binding cassette sub-family B member 6 antibody
    • ATP-binding cassette sub-family B member 6, mitochondrial antibody
    • DUH3 antibody
    • LAN antibody
    • MCOPCB7 antibody
    • Mitochondrial ABC transporter 3 antibody
    • mitochondrial antibody
    • Mt ABC transporter 3 antibody
    • Mt-ABC transporter 3 antibody
    • MTABC3 antibody
    • P glycoprotein related protein antibody
    • P-glycoprotein-related protein antibody
    • PRP antibody
    • Ubiquitously expressed mammalian ABC half transporter antibody
    • Ubiquitously-expressed mammalian ABC half transporter antibody
    • UMAT antibody
    see all

Images

  • Paraffin-embedded human testis tissue stained for ABCB6/PRP using ab224575 at 1/20 dilution in immunohistochemical analysis.

  • PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for ABCB6/PRP (green) using ab224575 at 4 µg/ml in ICC/IF.

References

ab224575 has not yet been referenced specifically in any publications.

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