Overview

  • Product name

  • Description

    Rabbit polyclonal to ABCB7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 449-705 of Human ABCB7 (Uniprot ID: O75027).

  • Positive control

    • A431, 293T, Raji whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab151992 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 83 kDa.

Target

  • Function

    Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.
  • Involvement in disease

    Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310]. ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis.
  • Sequence similarities

    Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 1 ABC transporter domain.
  • Cellular localization

    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ABC transporter 7 protein antibody
    • ABC7 antibody
    • Abcb7 antibody
    • ABCB7_HUMAN antibody
    • ASAT antibody
    • Atm1p antibody
    • ATP binding cassette 7 antibody
    • ATP binding cassette sub family B (MDR/TAP) member 7 antibody
    • ATP binding cassette sub family B member 7 antibody
    • ATP binding cassette sub family B member 7 mitochondrial antibody
    • ATP binding cassette transporter 7 antibody
    • ATP-binding cassette sub-family B member 7 antibody
    • ATP-binding cassette transporter 7 antibody
    • EST140535 antibody
    • MDR7 antibody
    • mitochondrial antibody
    • Multidrug resistance protein 7 antibody
    • P-glycoprotein 7 antibody
    • PGP7 antibody
    see all

Images

  • Anti-ABCB7 antibody (ab151992) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 83 kDa



    7.5% SDS PAGE

References

This product has been referenced in:

  • Maio N  et al. Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica N/A:N/A (2019). Read more (PubMed: 30765471) »
  • Maio N  et al. A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. Cell Metab 25:945-953.e6 (2017). Read more (PubMed: 28380382) »
See all 2 Publications for this product

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