Overview

  • Product name

  • Description

    Goat polyclonal to ABCC9

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species

    Goat
  • Specificity

    ab133150 is expected to recognize isoforms NP_005682.2 and NP_064693.2.
  • Species reactivity


    Predicted to work with: Cow, Dog, Human
  • Immunogen

    Synthetic peptide:

    C-TSEYSINNTGKAD

    with a Cysteine residue linker, corresponding to internal sequence amino acids 1019-1031 of Human ABCC9 (NP_005682.2; NP_064693.2).

Properties

Applications

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 174 kDa. Preliminary experiments gave an approx 90kDa band in Human Testis lysates and 100kDa in Rat Testis lysates after 0.1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 170kDa according to NP_005682.2. The 90kDa band was successfully blocked by incubation with the immunizing peptide.

Target

  • Function

    Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
  • Involvement in disease

    Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O) [MIM:608569]; also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12) [MIM:614050]. ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
  • Sequence similarities

    Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ABC37 antibody
    • abcC9 antibody
    • ABCC9_HUMAN antibody
    • AI414027 antibody
    • AI449286 antibody
    • ATFB12 antibody
    • ATP-binding cassette sub-family C member 9 antibody
    • ATP-binding cassette transporter sub-family C member 9 antibody
    • ATP-binding cassette, sub-family C (CFTR/MRP), member 9 antibody
    • CANTU antibody
    • CMD1O antibody
    • FLJ36852 antibody
    • Sulfonylurea receptor 2 antibody
    • Sulfonylurea-binding protein 2 antibody
    • SUR2 antibody
    • SUR2A antibody
    • SUR2B antibody
    see all

References

ab133150 has not yet been referenced specifically in any publications.

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