Overview

  • Product name

  • Description

    Rabbit polyclonal to ABCG5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human ABCG5 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q9H222

  • Positive control

    • Rat liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab214288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
  • Tissue specificity

    Strongly expressed in the liver, lower levels in the small intestine and colon.
  • Involvement in disease

    Defects in ABCG5 are a cause of sitosterolemia (STSL) [MIM:210250]; also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.
  • Sequence similarities

    Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
    Contains 1 ABC transmembrane type-2 domain.
    Contains 1 ABC transporter domain.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Abcg5 antibody
    • ABCG5_HUMAN antibody
    • ATP binding cassette sub family G (WHITE) member 5 (sterolin 1) antibody
    • ATP binding cassette sub family G member 5 antibody
    • ATP-binding cassette sub-family G member 5 antibody
    • ATP-binding cassette, sub-family G (WHITE), member 5 antibody
    • Sterolin 1 antibody
    • Sterolin-1 antibody
    • STSL antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat liver tissue, labeling ABCG5 with ab214288 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab214288 has not yet been referenced specifically in any publications.

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