Overview

  • Product name

  • Description

    Rabbit polyclonal to ABHD12
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (Human)

  • Positive control

    • THP1 cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG

Applications

Our Abpromise guarantee covers the use of ab87048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/1000 - 1/4000. Detects a band of approximately 45 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways.
    • Involvement in disease

      Defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC) [MIM:612674]. PHARC is a slowly progressive neurologic disorder with a variable phenotype resembling Refsum disease. Clinical features include sensorineural hearing loss, visual problems related to cataracts, retinitis pigmentosa, pes cavus, ataxic and/or spastic gait disturbances with a progressive sensorimotor peripheral neuropathy. Other features include hyporeflexia, hyperreflexia, extensor plantar responses.
    • Sequence similarities

      Belongs to the serine esterase family.
    • Post-translational
      modifications

      Glycosylated.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • 2-arachidonoylglycerol hydrolase antibody
      • 6330583M11Rik antibody
      • ABD12_HUMAN antibody
      • ABHD12 antibody
      • ABHD12A antibody
      • Abhydrolase domain containing protein 12 antibody
      • Abhydrolase domain-containing protein 12 antibody
      • AI431047 antibody
      • AW547313 antibody
      • BEM46L2 antibody
      • C20orf22 antibody
      • Monoacylglycerol lipase ABHD12 antibody
      • RP23-241M12.2 antibody
      see all

    Images

    • All lanes : Anti-ABHD12 antibody (ab87048) at 1/2000 dilution

      All lanes : THP1 cell lysate

      Lysates/proteins at 60 µg per lane.

      Predicted band size: 45 kDa
      Observed band size: 45 kDa

    References

    This product has been referenced in:

    • Joshi A  et al. Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids. J Biol Chem 293:16953-16963 (2018). Read more (PubMed: 30237167) »
    See 1 Publication for this product

    Customer reviews and Q&As

    Question
    Answer

    Thank you for contacting us.


    I am sorry that this antibody did not perform as stated on the datasheet. The purchase will be refunded back on to your credit card.

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