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  1. Link

    abl1-peptide-ab204848.pdf

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Signal Transduction Protein Phosphorylation Tyrosine Kinases Other
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ABL1 peptide (ab204848)

  • Datasheet
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Abpromise

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Key features and details

  • Suitable for: HPLC

Description

  • Product name

    ABL1 peptide
    See all ABL1 proteins and peptides
  • Animal free

    No
  • Nature

    Synthetic
    • Sequence

      EAIYAAPFAKKK

Associated products

  • Recombinant Protein

    • Recombinant human MAP4K3/GLK protein (Tagged) (ab177265)
    • Recombinant human LTK protein (ab179494)
    • Recombinant human ABL2 protein (ab51259)
    • Recombinant human ABL1 protein (ab69810)

Specifications

Our Abpromise guarantee covers the use of ab204848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

  • Form

    Lyophilized
  • Additional notes

    ab204848 (ABL1 peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab69810 (Active human ABL1 protein fragment)
    ab51259 (Active human ABL2 protein fragment)
    ab179494 (Active human LTK protein fragment)
    ab177265 (Active human GLK protein fragment)

     

     

    Previously labelled as c Abl.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in distilled water to a final concentration of 1mg/ml

General Info

  • Alternative names

    • Abelson murine leukemia viral oncogene homolog 1
    • Abelson tyrosine protein kinase 1
    • ABL
    • Abl 1
    • ABL proto oncogene 1 non receptor tyrosine kinase
    • ABL1
    • ABL1_HUMAN
    • bcr/abl
    • bcr/c abl oncogene protein
    • c ABL
    • c abl oncogene 1 non receptor tyrosine kinase
    • c abl oncogene 1 receptor tyrosine kinase
    • c ABL1
    • JTK7
    • p150
    • Proto oncogene tyrosine protein kinase ABL1
    • Proto-oncogene c-Abl
    • Tyrosine-protein kinase ABL1
    • v abl
    • v abl Abelson murine leukemia viral oncogene homolog 1
    see all
  • Function

    Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
  • Tissue specificity

    Widely expressed.
  • Involvement in disease

    Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Post-translational
    modifications

    Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation (By similarity). Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic translocation.
    Isoform IB is myristoylated on Gly-2.
  • Cellular localization

    Cytoplasm > cytoskeleton. Nucleus. Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane. The myristoylated c-ABL protein is reported to be nuclear.
  • Target information above from: UniProt accession P00519 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab204848? Please let us know so that we can cite the reference in this datasheet.

    ab204848 has not yet been referenced specifically in any publications.

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