ABL1 peptide (ab204848)
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Description
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Product name
ABL1 peptide
See all ABL1 proteins and peptides -
Animal free
No -
Nature
Synthetic -
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Sequence
EAIYAAPFAKKK
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Associated products
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Recombinant Protein
Specifications
Our Abpromise guarantee covers the use of ab204848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
HPLC
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Form
Lyophilised -
Additional notes
ab204848 (ABL1 peptide) can be utilized as a substrate for the following active protein kinases:
ab69810 (Active human ABL1 protein fragment)
ab51259 (Active human ABL2 protein fragment)
ab179494 (Active human LTK protein fragment)
ab177265 (Active human GLK protein fragment)Previously labelled as c Abl.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
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ReconstitutionDilute peptide in distilled water to a final concentration of 1mg/ml
General Info
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Alternative names
- Abelson murine leukemia viral oncogene homolog 1
- Abelson tyrosine protein kinase 1
- ABL
see all -
Function
Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. -
Tissue specificity
Widely expressed. -
Involvement in disease
Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain. -
Post-translational
modificationsPhosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation (By similarity). Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for cytoplasmic translocation.
Isoform IB is myristoylated on Gly-2. -
Cellular localization
Cytoplasm > cytoskeleton. Nucleus. Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane. The myristoylated c-ABL protein is reported to be nuclear. - Information by UniProt
Datasheets and documents
References
ab204848 has not yet been referenced specifically in any publications.
