Anti-ABO antibody [BRIC231] (ab33404)
Key features and details
- Mouse monoclonal [BRIC231] to ABO
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-ABO antibody [BRIC231]
See all ABO primary antibodies -
Description
Mouse monoclonal [BRIC231] to ABO -
Host species
Mouse -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human ABO.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: Tris buffer -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
BRIC231 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Function
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. -
Pathway
Protein modification; protein glycosylation. -
Sequence similarities
Belongs to the glycosyltransferase 6 family. -
Domain
The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis. -
Post-translational
modificationsThe soluble form derives from the membrane form by proteolytic processing. -
Cellular localization
Golgi apparatus > Golgi stack membrane. Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid. - Information by UniProt
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Database links
- Entrez Gene: 28 Human
- Omim: 110300 Human
- SwissProt: P16442 Human
- Unigene: 654423 Human
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Alternative names
- A transferase antibody
- Abo antibody
- B transferase antibody
see all
References (2)
ab33404 has been referenced in 2 publications.
- Purohit S et al. Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins. Nat Commun 9:258 (2018). PubMed: 29343722
- Gao C et al. Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array. J Biol Chem 289:16462-77 (2014). PubMed: 24753245
