ABT-263, Bcl-2 family protein inhibitor (ab218114)

Overview

  • Product name

    ABT-263, Bcl-2 family protein inhibitor
  • Description

    Potent, small molecule Bcl-2 family protein inhibitor
  • Alternative names

    • A-855071
    • ABT263
    • Navitoclax
  • Biological description

    Potent, small molecule Bcl-2 family protein inhibitor (Ki’s of <1 nM for Bcl-2, Bcl-XL and Bcl-w). Orally bioavailable. Displays anticancer properties. Selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and disrupts Bcl-2/Bcl-XL interactions with pro-death proteins, leading to the initiation of apoptosis. Induces Bax translocation, cytochrome c release, and subsequent apoptosis.

  • Purity

    > 98%
  • CAS Number

    923564-51-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
  • Molecular weight

    974.61
  • Molecular formula

    C47H55ClF3N5O6S3
  • PubChem identifier

    24978538
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
  • Source

    Synthetic

References

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