ABT-751 (E-7010), Antimitotic agent (ab142973)

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Overview

  • Product name

    ABT-751 (E-7010), Antimitotic agent

  • Description

    Antimitotic agent. Microtubule polymerization inhibitor.

  • Alternative names

    • E-7010

  • Biological description

    Antimitotic agent. Microtubule polymerization inhibitor. Induces G2M phase cell cycle arrest and apoptosis. Disrupts tumor vasculature. Shows antitumor effects in vivo. Orally active.

  • Purity

    > 99%

  • CAS Number

    141430-65-1

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[2-(4-Hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide

  • Molecular weight

    371.41

  • Molecular formula

    C18H17N3O4S

  • PubChem identifier

    3035714

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Luo Y  et al. ABT-751, a novel tubulin-binding agent, decreases tumor perfusion and disrupts tumor vasculature. Anticancer Drugs 20:483-92 (2009). Read more (PubMed: 19398903) »
  • Cho SY  et al. Plasma and cerebrospinal fluid pharmacokinetics of intravenously administered ABT-751 in non-human primates. Cancer Chemother Pharmacol 60:563-7 (2007). Read more (PubMed: 17187251) »
  • Silver M  et al. Evaluation of the oral antimitotic agent (ABT-751) in dogs with lymphoma. J Vet Intern Med 26:349-54 (0). Read more (PubMed: 22369215) »

Publishing research using ab142973? Please let us know so that we can cite the reference in this datasheet.

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