Overview

  • Product name
    Ac-IEPD-CHO, granzyme B and caspase-8 inhibitor
  • Description
    Reversible granzyme B and caspase-8 inhibitor
  • Biological description
    Reversible granzyme B (Ki = 80 nM) and caspase-8 inhibitor. Also inhibits caspase-7 (Ki = 550 nM) and apoptosis in multiple biological systems.
  • Purity
    > 95%
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Hong IS  et al. Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells. J Clin Endocrinol Metab 93:3179-85 (2008). Read more (PubMed: 18477660) »
  • Agniswamy J  et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J 274:4752-65 (2007). Read more (PubMed: 17697120) »
  • Velthuis JH  et al. Distinct intracellular signaling in tumor necrosis factor-related apoptosis-inducing ligand- and CD95 ligand-mediated apoptosis. J Biol Chem 277:24631-7 (2002). Read more (PubMed: 11980895) »
  • Willoughby CA  et al. Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett 12:2197-200 (2002). Read more (PubMed: 12127536) »
  • Rotonda J  et al. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. Chem Biol 8:357-68 (2001). Read more (PubMed: 11325591) »

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