Overview

  • Product name

    Ac-SAHA, Derivative of SAHA
  • Description

    Derivative of SAHA; Caged HDAC inhibitor.
  • Biological description

    (7-diethylaminocoumarin-4-yl)methyl ester derivative of SAHA (suberoylanilide hydroxamic acid), a potent non-selective histone deacetylase (HDAC) inhibitor. Caged HDAC inhibitor, which releases SAHA upon cleavage of the photolabile (7-diethylaminocoumarin-4-yl)methyl protecting group in response to photoirradiation. Shows essentially no HDAC-inhibitory activity prior to photoirradiation.

  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-{[7-(Diethylamino)-2-oxo-2H-chromen-4-yl]methoxy}-N'-phenyloctanediamide

  • Molecular weight

    493.60
  • Molecular formula

    C28H35N3O5
  • Storage instructions

    Store at +4°C. Store In the Dark.
  • Solubility overview

    Soluble in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN(CC)c1ccc3c(c1)OC(=O)C=C3CONC(=O)CCCCCCC(=O)Nc2ccccc2
  • Source

    Synthetic

References

This product has been referenced in:

  • Ieda N  et al. (7-Diethylaminocoumarin-4-yl)methyl ester of suberoylanilide hydroxamic acid as a caged inhibitor for photocontrol of histone deacetylase activity. Bioorg Med Chem 24:2789-93 (2016). Read more (PubMed: 27143132) »

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