Key features and details
- Potent, selective amylin receptor antagonist
- CAS Number: 151804-77-2
- Purity: > 95%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Product nameAC187, amylin receptor antagonist
DescriptionPotent, selective amylin receptor antagonist
Potent, selective amylin receptor antagonist (IC50 = 0.48 nM). Displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity following reduced activation of caspases, XIAP and BID in vitro. Role in glucose homeostasis.
SequenceVLGKLSQELHKLQTYPRTNTGSNTY (Modifications: N-terminal acetyl; C-terminal amide)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141150 has been referenced in 1 publication.
- Li Z et al. Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake. Cell Metab 22:1059-67 (2015). PubMed: 26655697