Overview

  • Product name

    Anti-ACAD8 antibody
  • Description

    Rabbit polyclonal to ACAD8
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Fusion protein corresponding to Human ACAD8. (Near the C terminal; BC001964).
    Database link: Q9UKU7

  • Positive control

    • Human thyroid cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/15 - 1/50.

Target

  • Function

    Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.
  • Tissue specificity

    Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney.
  • Pathway

    Amino-acid degradation; L-valine degradation.
  • Involvement in disease

    Defects in ACAD8 are the cause of isobutyryl-CoA dehydrogenase deficiency (IBDD) [MIM:611283]. The symptoms of IBDD generally appear until late in infancy or in childhood and can include poor feeding and growth (failure to thrive), a weakened and enlarged heart (dilated cardiomyopathy), seizures, and low numbers of red blood cells (anemia).
  • Sequence similarities

    Belongs to the acyl-CoA dehydrogenase family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACAD 8 antibody
    • ACAD-8 antibody
    • ACAD8 antibody
    • ACAD8_HUMAN antibody
    • Activator-recruited cofactor 42 kDa component antibody
    • Acyl CoA dehydrogenase family member 8 antibody
    • Acyl Coenzyme A dehydrogenase family member 8 antibody
    • Acyl-CoA dehydrogenase family member 8 antibody
    • ARC42 antibody
    • FLJ22590 antibody
    • IBD antibody
    • Isobutyryl-CoA dehydrogenase antibody
    • Isobutyryl-CoA dehydrogenase, mitochondrial antibody
    • mitochondrial antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling ACAD8 with ab197795 at 1/20 dilution.

References

ab197795 has not yet been referenced specifically in any publications.

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