Overview

  • Product name

    Anti-ACADVL/VLCAD antibody - C-terminal
    See all ACADVL/VLCAD primary antibodies
  • Description

    Goat polyclonal to ACADVL/VLCAD - C-terminal
  • Host species

    Goat
  • Specificity

    ab223685 is expected to recognize both reported isoforms (NP_000009.1; NP_001029031.1).
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Cynomolgus monkey
  • Immunogen

    Synthetic peptide corresponding to Human ACADVL/VLCAD aa 587-599 (C terminal) (Cysteine residue). NP_000009.1; NP_001029031.1.
    Sequence:

    C-RSLSEGHPTAQHE


    Database link: P49748

  • Positive control

    • WB: Human heart lysate.
  • General notes

    Previously labelled as ACADVL. 

Properties

Applications

Our Abpromise guarantee covers the use of ab223685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 70 kDa).

Target

  • Function

    Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accomodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.
  • Pathway

    Lipid metabolism; mitochondrial fatty acid beta-oxidation.
  • Involvement in disease

    Defects in ACADVL are the cause of acyl-CoA dehydrogenase very long chain deficiency (ACADVLD) [MIM:201475]. ACADVLD is an autosomal recessive disease which leads to impaired long-chain fatty acid beta-oxidation. It is clinically heterogeneous, with three major phenotypes: a severe childhood form, with early onset, high mortality, and high incidence of cardiomyopathy; a milder childhood form, with later onset, usually with hypoketotic hypoglycemia as the main presenting feature, low mortality, and rare cardiomyopathy; and an adult form, with isolated skeletal muscle involvement, rhabdomyolysis, and myoglobinuria, usually triggered by exercise or fasting.
  • Sequence similarities

    Belongs to the acyl-CoA dehydrogenase family.
  • Cellular localization

    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACAD 6 antibody
    • ACAD6 antibody
    • ACADV_HUMAN antibody
    • Acadvl antibody
    • Acyl CoA dehydrogenase very long chain antibody
    • Acyl Coenzyme A dehydrogenase very long chain antibody
    • LCACD antibody
    • mitochondrial antibody
    • Very long chain specific acyl CoA dehydrogenase antibody
    • Very long chain specific acyl CoA dehydrogenase mitochondrial antibody
    • Very long-chain specific acyl-CoA dehydrogenase antibody
    • VLCAD antibody
    see all

Images

  • Anti-ACADVL/VLCAD antibody - C-terminal (ab223685) at 1 µg/ml + Human heart lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 70 kDa
    Observed band size: 70 kDa



    Primary incubation was 1 hour.

References

ab223685 has not yet been referenced specifically in any publications.

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