Key features and details
- Rabbit polyclonal to ACD
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-ACD antibody
See all ACD primary antibodies
DescriptionRabbit polyclonal to ACD
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Human
- U-2 OS cells.
This product was previously labelled as PTOP
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab220740 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.
Fixation/Permeabilization: PFA/Triton X-100.
FunctionComponent of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.
Cellular localizationNucleus. Chromosome > telomere.
- Information by UniProt
- Acd antibody
- ACD_HUMAN antibody
- Adrenocortical dysplasia homolog antibody
ab220740 has not yet been referenced specifically in any publications.