Overview

  • Product name

    Acemetacin, cyclooxygenase inhibitor
  • Description

    NSAID. Cyclooxygenase inhibitor
  • Biological description

    NSAID. Cyclooxygenase inhibitor. Prodrug glycolic acid ester of indometacin. Metabolized to cyclooxygenase inhibitor, indometacin, which has anti-inflammatory effects. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    53164-05-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
  • Molecular weight

    415.83
  • Molecular formula

    C21H18ClNO6
  • PubChem identifier

    1981
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OCC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gil-Flores M  et al. Acemetacin antinociceptive mechanism is not related to NO or K+ channel pathways. Methods Find Exp Clin Pharmacol 32:101-5 (2010). Read more (PubMed: 20401346) »
  • Chávez-Piña AE  et al. Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin. Br J Pharmacol 152:930-8 (2007). Read more (PubMed: 17876306) »
  • Chávez-Piña AE  et al. Pharmacokinetics of acemetacin and its active metabolite indomethacin in rats during acute hepatic damage and liver regeneration. Ann Hepatol 8:141-7 (0). Read more (PubMed: 19502658) »

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