Overview

  • Product name

    Acetaminophen, COX-3 inhibitor
  • Description

    Selective COX-3 inhibitor
  • Alternative names

    • Paracetamol
  • Biological description

    Selective COX-3 inhibitor (IC50 = 460 μM). NSAID with widely used analgesic and antipyretic effects. Blood-brain barrier permeable.
  • Purity

    > 98%
  • CAS Number

    103-90-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bulku E  et al. Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Curr Neurovasc Res 9:58-71 (2012). Read more (PubMed: 22272768) »
  • Mallet C  et al. Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia. Pain 139:190-200 (2008). Read more (PubMed: 18485596) »
  • Chandrasekharan NV  et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A 99:13926-31 (2002). Read more (PubMed: 12242329) »

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