Acetyl-L-carnitine hydrochloride, L-Carnitine derivative (ab145570)

Overview

  • Product name

    Acetyl-L-carnitine hydrochloride, L-Carnitine derivative
  • Description

    L-Carnitine (ab142499) derivative that enables CoA function. Antioxidant.
  • Alternative names

    • Acetyl-L-Carnitine HCL
    • Acetylcarnitine hydrochloride
    • ALC
    • ALCAR
  • Biological description

    Enables CoA function. Lowers oxidative stress marker levels. Improves mitochondrial function. Blood-brain barrier permeable. Exhibits antidepressant, neuroprotective, analgesic and antinociceptive activities in vivo.

  • Purity

    > 98%
  • CAS Number

    5080-50-2
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    239.70
  • Molecular formula

    C9H17NO4.HCl
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OC(CC(=O)O)C[N+](C)(C)C.[Cl-]
  • Source

    Synthetic

References

This product has been referenced in:

  • Cuccurazzu B  et al. Upregulation of mGlu2 Receptors via NF-?B p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine. Neuropsychopharmacology 38:2220-30 (2013). Read more (PubMed: 23670591) »
  • Onofrj M  et al. Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. Expert Rev Neurother 13:925-36 (2013). Read more (PubMed: 23965166) »
  • Virmani A  et al. Acetyl-L-Carnitine Modulates TP53 and IL10 Gene Expression Induced by 3-NPA Evoked Toxicity in PC12 Cells. Curr Neuropharmacol 9:195-9 (2011). Read more (PubMed: 21886589) »
  • Vivoli E  et al. Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy. Neuroscience 167:1168-74 (2010). Read more (PubMed: 20302919) »
  • Epis R  et al. Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons. Eur J Pharmacol 597:51-6 (2008). Read more (PubMed: 18801359) »
  • Ghelardini C  et al. Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats. Neuropharmacology 43:1180-7 (2002). Read more (PubMed: 12504925) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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