Acinus peptide (ab8367)

Our Abpromise guarantee covers the use of ab8367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Stability and Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Alternative names
- ACIN 1
- ACIN1
- ACINU_HUMAN
- Acinus
- ACN
- Apoptotic chromatin condensation inducer 1
- Apoptotic chromatin condensation inducer in the nucleus
- DKFZp667N107
- fSAP152
- functional spliceosome-associated protein 152
- KIAA0670
see all
Function

Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
Tissue specificity

Ubiquitous.
Sequence similarities

Contains 1 SAP domain.
Post-translational
modifications

Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
Cellular localization

Nucleus.
Target information above from: UniProt accession Q9UKV3 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

ab8367 has not yet been referenced specifically in any publications.

Publishing research using ab8367? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"