Overview

  • Product name

    Acitretin, lipophilic retinoid
  • Description

    Synthetic, highly lipophilic retinoid
  • Biological description

    Synthetic, highly lipophilic retinoid. Etretinate (ab142612) metabolite with a shorter half-life. Increases ADAM10 gene expression. Induces keratinocyte differentiation and reduces epidermal hyperplasia in vivo. Orally active. Blood-brain barrier permeable.
  • Purity

    > 95%
  • CAS Number

    55079-83-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Freese C  et al. A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug. PLoS One 9:e91003 (2014). Read more (PubMed: 24608847) »
  • Silva FS  et al. Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: potential mechanisms of hepatotoxicity. Toxicology 306:93-100 (2013). Read more (PubMed: 23384448) »
  • Chien DS  et al. Systemic pharmacokinetics of acitretin, etretinate, isotretinoin, and acetylenic retinoids in guinea pigs and obese rats. Drug Metab Dispos 20:211-7 (0). Read more (PubMed: 1352212) »

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