Overview

  • Product name

    Acivicin, gamma-glutamyl transpeptidase inhibitor
  • Description

    γ-glutamyl transpeptidase inhibitor
  • Biological description

    Potent, irreversible inhibitor of γ-glutamyl transpeptidase (GGT). Anticancer and antitumor activity in vivo. Prevents melanoma metastasis in vitro.
  • Purity

    > 98%
  • CAS Number

    42228-92-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
  • Molecular weight

    178.57
  • Molecular formula

    C5H7ClN2O3
  • PubChem identifier

    294641
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C(ON=C1Cl)C(C(=O)O)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lantum HB  et al. Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activities. Biochem Pharmacol 67:1421-6 (2004). Read more (PubMed: 15013858) »
  • Miles BW  et al. Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. J Biol Chem 277:4368-73 (2002). Read more (PubMed: 11729189) »
  • Roy S & Maity P Modulation of metastatic potential of B16F10 melanoma cells by acivicin: synergistic action of glutaminase and potentiation of cisplatin cytotoxicity. Asian Pac J Cancer Prev 8:301-6 (0). Read more (PubMed: 17696751) »

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