Anti-Aconitase 1/ACO1 (phospho S138) antibody (ab63260)

Overview

  • Product name

    Anti-Aconitase 1/ACO1 (phospho S138) antibody
    See all Aconitase 1/ACO1 primary antibodies
  • Description

    Rabbit polyclonal to Aconitase 1/ACO1 (phospho S138)
  • Host species

    Rabbit
  • Specificity

    ab63260 detects endogenous levels of Aconitase 1/ACO1 only when phosphorylated at serine 138.

  • Tested applications

    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human Aconitase 1/ACO1.

  • Positive control

    • Human ovary tissue
  • General notes

     This product was previously labelled as Aconitase 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab63260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
IHC-P 1/50 - 1/100.

Target

  • Function

    Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
    Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
  • Sequence similarities

    Belongs to the aconitase/IPM isomerase family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACO 1 antibody
    • ACO1 antibody
    • ACOC_HUMAN antibody
    • Aconitase 1 soluble antibody
    • Aconitase antibody
    • Aconitase1 antibody
    • Aconitate hydratase antibody
    • ACONS antibody
    • Citrate hydro lyase antibody
    • Citrate hydro-lyase antibody
    • Cytoplasmic aconitate hydratase antibody
    • Ferritin repressor protein antibody
    • IRE BP 1 antibody
    • IRE-BP 1 antibody
    • IREB 1 antibody
    • IREB1 antibody
    • IREBP antibody
    • IREBP1 antibody
    • Iron regulatory protein 1 antibody
    • Iron responsive element binding protein 1 antibody
    • Iron-responsive element-binding protein 1 antibody
    • IRP 1 antibody
    • IRP1 antibody
    • OTTHUMP00000045233 antibody
    see all

Images

  • Immunohistochemical analysis of Aconitase 1/ACO1 (phospho S138) expression in paraffin-embedded human ovary tissue using ab63260 at 1/50. Left image: untreated. Right image: sample treated with immunising phosphopeptide.

References

ab63260 has not yet been referenced specifically in any publications.

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