Overview

  • Product name

  • Description

    Rabbit polyclonal to ACOX1/AOX
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human ACOX1/AOX aa 361-649.
    Database link: NM_007292

  • Positive control

    • Human fetal liver, HEK293 and MCF7 cell lysates; Human breast carcinoma tissue.
  • General notes

    Previously labelled as ACOX1. 
     

Properties

Applications

Our Abpromise guarantee covers the use of ab128549 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 74 kDa (predicted molecular weight: 74 kDa).
IHC-P 1/100 - 1/500.

Target

  • Function

    Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
  • Tissue specificity

    Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.
  • Pathway

    Lipid metabolism; peroxisomal fatty acid beta-oxidation.
  • Involvement in disease

    Adrenoleukodystrophy, pseudoneonatal
  • Sequence similarities

    Belongs to the acyl-CoA oxidase family.
  • Cellular localization

    Peroxisome.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACOX antibody
    • ACOX1 antibody
    • ACOX1_HUMAN antibody
    • Acyl CoA oxidase 1 palmitoyl antibody
    • Acyl CoA oxidase straight chain antibody
    • AOX antibody
    • EC 1.3.3.6 antibody
    • PALMCOX antibody
    • Palmitoyl CoA oxidase antibody
    • Palmitoyl-CoA oxidase antibody
    • Peroxisomal acyl coenzyme A oxidase 1 antibody
    • Peroxisomal acyl-coenzyme A oxidase 1 antibody
    • Peroxisomal fatty acyl CoA oxidase antibody
    • SCOX antibody
    • Straight chain acyl CoA oxidase antibody
    • Straight-chain acyl-CoA oxidase antibody
    see all

Images

  • ab128549, at 1/100 dilution, staining ACOX1/AOX in Formalin-fixed paraffin-embedded Human breast carcinoma tissue Immunohistochemistry.

  • All lanes : Anti-ACOX1/AOX antibody (ab128549) at 1/1000 dilution

    Lane 1 : Human fetal liver lysate
    Lane 2 : HEK293 lysate
    Lane 3 : MCF7 lysate

    Predicted band size: 74 kDa

References

This product has been referenced in:

  • Kim S  et al. Differential expression of lipid metabolism-related proteins in different breast cancer subtypes. PLoS One 10:e0119473 (2015). Read more (PubMed: 25751270) »
  • Jung YY  et al. Expression of Lipid Metabolism-Related Proteins in Metastatic Breast Cancer. PLoS One 10:e0137204 (2015). IHC . Read more (PubMed: 26334757) »
See all 2 Publications for this product

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