Overview

  • Product name

  • Description

    Rabbit polyclonal to ACSL6/ACS2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human ACSL6/ACS2 aa 458-697.
    Database link: Q9UKU0

  • Positive control

    • WB: Mouse liver, heart, brain and gonadal lysates; Jurkat, Raji and K562 whole cell lysates. IHC-P: Human brain and adrenal gland tissues.
  • General notes

     This product was previously labelled as ACSL6

     

Properties

Applications

Our Abpromise guarantee covers the use of ab229958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/1000 - 1/5000. Detects a band of approximately 78 kDa (predicted molecular weight: 78 kDa).

Target

  • Relevance

    ACSL6 belongs to the ATP-dependent AMP-binding enzyme family. It is involved in the activation of long-chain fatty acids for both synthesis of cellular lipids and degradation via beta-oxidation. ACSL6 plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. ACSL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. There are three named isoforms.
  • Cellular localization

    Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • Database links

  • Alternative names

    • ACS2 antibody
    • Acyl CoA synthetase long chain family member 6 antibody
    • FACL6 antibody
    • Fatty acid Coenzyme A ligase, long chain 6 antibody
    • LACS 6 antibody
    • LACS2 antibody
    • LACS5 antibody
    • Long chain acyl CoA synthetase 6 antibody
    • Long chain fatty acid CoA ligase 6 antibody
    • Long fatty acyl CoA synthetase 2 antibody
    see all

Images

  • All lanes : Anti-ACSL6/ACS2 antibody (ab229958) at 1/1000 dilution

    Lane 1 : Mouse liver lysate
    Lane 2 : Mouse heart lysate
    Lane 3 : Mouse brain lysate
    Lane 4 : Mouse gonadal lysate
    Lane 5 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate
    Lane 6 : Raji (human Burkitt's lymphoma cell line) whole cell lysate
    Lane 7 : K562 (human chronic myelogenous leukemia cell line from bone marrow) whole cell lysate

    Secondary
    All lanes : Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 78 kDa
    Observed band size: 78 kDa

  • Paraffin-embedded human brain tissue stained for ACSL6/ACS2 using ab229958 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human adrenal gland tissue stained for ACSL6/ACS2 using ab229958 at 1/100 dilution in immunohistochemical analysis.

References

ab229958 has not yet been referenced specifically in any publications.

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