Overview

  • Product name

  • Description

    Rabbit polyclonal to ACSL6/ACS2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human ACSL6/ACS2 aa 499-548. The exact sequence is proprietary.
    Database link: Q9UKU0

  • Positive control

    • WB: COLO 205 and Jurkat cell extracts. IHC-P: Human skeletal muscle tissue.
  • General notes

     This product was previously labelled as ACSL6

     

Properties

Applications

Our Abpromise guarantee covers the use of ab230415 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB 1/500 - 1/1000. Predicted molecular weight: 78 kDa.

Target

  • Relevance

    ACSL6 belongs to the ATP-dependent AMP-binding enzyme family. It is involved in the activation of long-chain fatty acids for both synthesis of cellular lipids and degradation via beta-oxidation. ACSL6 plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. ACSL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. There are three named isoforms.
  • Cellular localization

    Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • Database links

  • Alternative names

    • ACS2 antibody
    • Acyl CoA synthetase long chain family member 6 antibody
    • FACL6 antibody
    • Fatty acid Coenzyme A ligase, long chain 6 antibody
    • LACS 6 antibody
    • LACS2 antibody
    • LACS5 antibody
    • Long chain acyl CoA synthetase 6 antibody
    • Long chain fatty acid CoA ligase 6 antibody
    • Long fatty acyl CoA synthetase 2 antibody
    see all

Images

  • All lanes : Anti-ACSL6/ACS2 antibody (ab230415) at 1/500 dilution

    Lane 1 : COLO 205 (human colon adenocarcinoma cell line) cell extract
    Lane 2 : Jurkat (human T cell leukemia cell line from peripheral blood) cell extract
    Lane 3 : COLO 205 cell extract with immunizing peptide

    Predicted band size: 78 kDa

  • Formalin-fixed, paraffin-embedded human skeletal muscle tissue stained for ACSL6/ACS2 using ab230415 at 1/100 dilution in immunohistochemical analysis.

References

ab230415 has not yet been referenced specifically in any publications.

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