ACTH (1-39) (human), endogenous melanocortin receptor 2 (MC2) agonist (ab141151)

Overview

  • Product name

    ACTH (1-39) (human), endogenous melanocortin receptor 2 (MC2) agonist
  • Description

    Potent, endogenous melanocortin receptor 2 (MC2) agonist
  • Biological description

    Potent, endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamo-pituitary-adrenal (HPA) stress axis with an important role in the pathogenesis of obesity and metabolic syndrome.
  • Purity

    > 95%
  • CAS Number

    12279-41-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bertolini A  et al. Brain effects of melanocortins. Pharmacol Res 59:13-47 (2009). Read more (PubMed: 18996199) »
  • Iwen KA  et al. Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes. J Endocrinol 196:465-72 (2008). Read more (PubMed: 18310442) »
  • Al-Majed HT  et al. ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans. J Endocrinol 180:155-66 (2004). Read more (PubMed: 14709154) »
  • Kapas S  et al. Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137:3291-4 (1996). Read more (PubMed: 8754753) »

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