ACTH (4-10) (human), melanocortin receptor agonist fragment (ab142255)

Overview

  • Product name

    ACTH (4-10) (human), melanocortin receptor agonist fragment
  • Description

    Potent melanocortin receptor agonist and endogenous adrenocorticotropic hormone (ACTH) fragment
  • Biological description

    Potent melanocortin (MC) receptor agonist and endogenous adrenocorticotropic hormone (ACTH) fragment (EC50 values are 23 and 330 nM for MC3 and MC4 receptors respectively). Has multiple biological activities. Analgesic, neuroprotective and prevents ischemia-induced cardiac injury. Active in vivo.
  • Purity

    > 95%
  • CAS Number

    4037-01-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Juhasz B  et al. Adrenocorticotrope hormone fragment (4-10) attenuates the ischemia/reperfusion-induced cardiac injury in isolated rat hearts. Antioxid Redox Signal 9:1851-61 (2007). Read more (PubMed: 17715999) »
  • Ivanova DM  et al. Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax. Bull Exp Biol Med 143:5-8 (2007). Read more (PubMed: 18018999) »
  • Miwa H  et al. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. J Pharmacol Exp Ther 273:367-72 (1995). Read more (PubMed: 7714790) »
  • Strand FL  et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev Neurosci 4:321-63 (0). Read more (PubMed: 8275276) »

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