Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor (ab141058)

Overview

  • Product name

    Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor
  • Description

    Nucleic acid and protein synthesis inhibitor
  • Alternative names

    • Dactinomycin
  • Purity

    > 98%
  • General notes

    This product is hygroscopic and light-sensitive. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.

  • CAS Number

    50-76-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

  • Molecular weight

    1255.43
  • Molecular formula

    C62H86N12O16
  • PubChem identifier

    2019
  • Storage instructions

    Store at 4°C prior to reconstitution. Store In the Dark.
  • Solubility overview

    Ssoluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL.

  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
  • Source

    Streptomyces sp.

  • Research areas

References

This product has been referenced in:

  • Koba M & Konopa J [Actinomycin D and its mechanisms of action]. Postepy Hig Med Dosw (Online) 59:290-8 (2005). Read more (PubMed: 15995596) »
  • Narita Y  et al. Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. Cancer Chemother Pharmacol 45:149-56 (2000). Read more (PubMed: 10663630) »
  • Toku S  et al. Effects of low dose actinomycin D treatment in vivo on the biosynthesis of ribosomal proteins in rat liver. J Biochem 93:349-59 (1983). Read more (PubMed: 6132918) »
See all 2 Publications for this product

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