Overview

  • Product name

    Actinonin, Matrix metalloprotease (MMP) inhibitor
  • Description

    Potent MMP and peptide deformylase inhibitor
  • Biological description

    Potent MMP and peptide deformylase inhibitor. Shows potent activity against peptide deformylase, M, N, leucine, alanyl, dipeptidyl aminopeptidases, enkephalinase A, and meprin α and β. Shows antiproliferative effects. Shows male-specific anti-ischemic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    13434-13-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3R)-3-[[(1S)-1-[[(2S)-2-(Hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid
  • Molecular weight

    385.50
  • Molecular formula

    C19H35N3O5
  • PubChem identifier

    443600
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    OC[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](CC(=O)NO)CCCCC)C(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Takayama J  et al. Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. Eur J Pharmacol 581:157-63 (2008). Read more (PubMed: 18093581) »
  • Lee MD  et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest 114:1107-16 (2004). Read more (PubMed: 15489958) »
  • Chen DZ  et al. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry 39:1256-62 (2000). Read more (PubMed: 10684604) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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