Validated using a knockout cell line

Anti-active Caspase-3 antibody [E83-77] (ab32042)

Publishing research using ab32042? Please let us know so that we can cite the reference in this datasheet.

ab32042 has been referenced in 68 publications.

  • Dai Y  et al. Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-?B pathway. Chem Biol Interact 284:32-40 (2018). WB . PubMed: 29454613
  • Kong D  et al. Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195. Biomed Pharmacother 99:176-183 (2018). WB . PubMed: 29331856
  • Wang Z  et al. Long noncoding RNA maternally expressed gene 3 knockdown alleviates lipopolysaccharide-induced inflammatory injury by up-regulation of miR-203 in ATDC5 cells. Biomed Pharmacother 100:240-249 (2018). WB . PubMed: 29432995
  • Wang Y  et al. Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-?B signal pathways. Chem Biol Interact 290:44-51 (2018). WB ; Human . PubMed: 29782821
  • Zheng Z  et al. Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration. J Cell Mol Med 22:3086-3096 (2018). PubMed: 29575654
  • Deng B  et al. miR-371-5p suppresses the proliferative and migratory capacity of human nasopharyngeal carcinoma by targeting BCL2. Oncol Lett 15:9209-9215 (2018). PubMed: 29844823
  • Xu W  et al. Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Biomed Pharmacother 102:587-593 (2018). WB . PubMed: 29597092
  • Liu S  et al. Sinomenine inhibits lipopolysaccharide-induced inflammatory injury by regulation of miR-101/MKP-1/JNK pathway in keratinocyte cells. Biomed Pharmacother 101:422-429 (2018). WB ; Human . PubMed: 29501764
  • Allen H  et al. Human Placental-Derived Adherent Stromal Cells Co-Induced with TNF-a and IFN-? Inhibit Triple-Negative Breast Cancer in Nude Mouse Xenograft Models. Sci Rep 8:670 (2018). PubMed: 29330447
  • Lu HJ  et al. Mechanism of MicroRNA-708 Targeting BAMBI in Cell Proliferation, Migration, and Apoptosis in Mice With Melanoma via the Wnt and TGF-ß Signaling Pathways. Technol Cancer Res Treat 17:1533034618756784 (2018). PubMed: 29466930
  • Ma Y  et al. High expression of PRPS1 induces an anti-apoptotic effect in B-ALL cell lines and predicts an adverse prognosis in Chinese children with B-ALL. Oncol Lett 15:4314-4322 (2018). PubMed: 29541198
  • Zhang L  et al. MicroRNA-30b promotes lipopolysaccharide-induced inflammatory injury and alleviates autophagy through JNK and NF-?B pathways in HK-2 cells. Biomed Pharmacother 101:842-851 (2018). WB . PubMed: 29635893
  • Paech F  et al. Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis. Front Pharmacol 8:367 (2017). WB ; Human . PubMed: 28659801
  • Chen L  et al. MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. J Cell Mol Med 21:3347-3359 (2017). WB . PubMed: 28609022
  • Yu D  et al. RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1. Onco Targets Ther 10:2609-2619 (2017). PubMed: 28553126
  • Liu Y  et al. Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice. Int J Mol Med 40:357-366 (2017). PubMed: 28656204
  • Zhang J  et al. Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro. Mol Med Rep 16:3869-3876 (2017). WB ; Rat . PubMed: 28731195
  • Luo Z  et al. Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. Exp Ther Med 14:5379-5386 (2017). PubMed: 29285066
  • Wang C  et al. Safflor yellow B reduces hypoxia-mediated vasoconstriction by regulating endothelial micro ribonucleic acid/nitric oxide synthase signaling. Oncotarget 8:93551-93566 (2017). PubMed: 29212172
  • Wang Q  et al. Targeted interfering DEP domain containing 1 protein induces apoptosis in A549 lung adenocarcinoma cells through the NF-?B signaling pathway. Onco Targets Ther 10:4443-4454 (2017). PubMed: 28979136
  • Wang X  et al. Roles of miR-4463 in H2O2-induced oxidative stress in human umbilical vein endothelial cells. Mol Med Rep 16:3242-3252 (2017). PubMed: 28713907
  • Zhang Y  et al. AGO2 involves the malignant phenotypes and FAK/PI3K/AKT signaling pathway in hypopharyngeal-derived FaDu cells. Oncotarget 8:54735-54746 (2017). PubMed: 28903378
  • Deng YP  et al. Human bocavirus induces apoptosis and autophagy in human bronchial epithelial cells. Exp Ther Med 14:753-758 (2017). PubMed: 28672995
  • Wei M  et al. Knockdown of RNF2 induces cell cycle arrest and apoptosis in prostate cancer cells through the upregulation of TXNIP. Oncotarget 8:5323-5338 (2017). IHC . PubMed: 28029659
  • Ma R  et al. Extracellular DNA traps released by acute promyelocytic leukemia cells through autophagy. Cell Death Dis 7:e2283 (2016). PubMed: 27362801
  • Eshtad S  et al. hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Oncogenesis 5:e275 (2016). PubMed: 27918552
  • Su N  et al. Role of Wnt/ß-catenin pathway in inducing autophagy and apoptosis in multiple myeloma cells. Oncol Lett 12:4623-4629 (2016). PubMed: 28105169
  • Hou H  et al. Brahma-related gene 1 induces apoptosis in a p53-dependent manner in human rheumatoid fibroblast-like synoviocyte MH7A. Medicine (Baltimore) 95:e5241 (2016). PubMed: 28002318
  • Maynard J  et al. The use of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) as a pathway-specific biomarker with AZD8186, a PI3Kß/d inhibitor. EJNMMI Res 6:62 (2016). WB ; Mouse . PubMed: 27515445
  • Cao L  et al. A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. PLoS One 11:e0161025 (2016). Human . PubMed: 27525972
  • Wang Y  et al. MicroRNA-142-3p inhibits hypoxia/reoxygenation-induced apoptosis and fibrosis of cardiomyocytes by targeting high mobility group box 1. Int J Mol Med 38:1377-1386 (2016). WB ; Mouse . PubMed: 28025989
  • Guo Y  et al. Saussurea tridactyla Sch. Bip.-derived polysaccharides and flavones reduce oxidative damage in ultraviolet B-irradiated HaCaT cells via a p38MAPK-independent mechanism. Drug Des Devel Ther 10:389-403 (2016). WB, ICC/IF ; Human . PubMed: 26855564
  • Teplyuk NM  et al. Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med 8:268-87 (2016). IHC-Fr . PubMed: 26881967
  • Wang X  et al. Therapeutic Potential of Delivering Arsenic Trioxide into HPV-Infected Cervical Cancer Cells Using Liposomal Nanotechnology. Nanoscale Res Lett 11:94 (2016). ICC/IF ; Human . PubMed: 26887578
  • Tura A  et al. Biocompatibility of the vital dye Acid Violet-17 on retinal pigment epithelial cells. Clin Ophthalmol 10:1435-45 (2016). PubMed: 27536056
  • Chi HC  et al. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death Dis 7:e2324 (2016). WB . PubMed: 27490929
  • Zhao X  et al. Effects of 17-AAG on the cell cycle and apoptosis of H446 cells and the associated mechanisms. Mol Med Rep 14:1067-74 (2016). WB ; Human . PubMed: 27279418
  • Shen H  et al. Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer. Oncotarget 7:60407-60418 (2016). WB . PubMed: 27494865
  • Baldeyron C  et al. TIPIN depletion leads to apoptosis in breast cancer cells. Mol Oncol 9:1580-98 (2015). PubMed: 26004086
  • Lue LF  et al. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices. Brain Pathol 25:469-80 (2015). IHC-FrFl ; Human . PubMed: 25186950
  • Zylicz JJ  et al. Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development. Elife 4:N/A (2015). IHC ; Mouse . PubMed: 26551560
  • Dong L  et al. Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. Int J Mol Sci 16:14655-68 (2015). WB ; Human . PubMed: 26132569
  • Dai W  et al. By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice. Oncotarget 6:13703-17 (2015). WB ; Human . PubMed: 25938543
  • Zuazua-Villar P  et al. Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Res 43:9776-87 (2015). WB ; Human . PubMed: 26271993
  • Zhu ZX  et al. bFGF-Regulating MAPKs Are Involved in High Glucose-Mediated ROS Production and Delay of Vascular Endothelial Cell Migration. PLoS One 10:e0144495 (2015). ICC/IF ; Human . PubMed: 26642060
  • Singh SK  et al. Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity. EMBO J 34:517-30 (2015). PubMed: 25586376
  • Zhang R  et al. Inhibition of autophagy using 3-methyladenine increases cisplatin-induced apoptosis by increasing endoplasmic reticulum stress in U251 human glioma cells. Mol Med Rep 12:1727-32 (2015). ICC/IF ; Human . PubMed: 25846607
  • Chu HL  et al. Novel antimicrobial peptides with high anticancer activity and selectivity. PLoS One 10:e0126390 (2015). WB ; Human . PubMed: 25970292
  • Yuksel A  et al. The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells. Hum Reprod 30:2926-35 (2015). ICC/IF ; Human . PubMed: 26466914
  • Stempin S  et al. Morphological and molecular characterization of the human breast epithelial cell line M13SV1 and its tumorigenic derivatives M13SV1-R2-2 and M13SV1-R2-N1. Cancer Cell Int 15:110 (2015). Functional Studies ; Human . PubMed: 26612978
  • Wang JF  et al. The molecular mechanisms of Tanshinone IIA on the apoptosis and arrest of human esophageal carcinoma cells. Biomed Res Int 2014:582730 (2014). WB ; Human . PubMed: 24829906
  • Valletta D  et al. Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma. Carcinogenesis 35:1407-15 (2014). Human . PubMed: 24590895
  • Gras B  et al. Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells. PLoS One 9:e92254 (2014). WB ; Human . PubMed: 24638100
  • Knutson SK  et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther 13:842-54 (2014). Human . PubMed: 24563539
  • Yeshayahu Y  et al. Testicular failure in a patient with G6PC3 deficiency. Pediatr Res N/A:N/A (2014). Human . PubMed: 24796372
  • Wiel C  et al. Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun 5:3792 (2014). PubMed: 24797322
  • Cao JX  et al. MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells. Cell Death Dis 5:e1426 (2014). PubMed: 25255219
  • Leifler KS  et al. Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer. J Immunol 190:4420-30 (2013). IHC-P ; Human . PubMed: 23509357
  • He G  et al. Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients. PLoS One 8:e59609 (2013). WB ; Human . PubMed: 23555723
  • Augert A  et al. PLA2R1 kills cancer cells by inducing mitochondrial stress. Free Radic Biol Med 65C:969-977 (2013). PubMed: 23994771
  • Xiao W  et al. Combination therapy with the histone deacetylase inhibitor LBH589 and radiation is an effective regimen for prostate cancer cells. PLoS One 8:e74253 (2013). WB . PubMed: 23991216
  • Hosoda R  et al. Differential cell-protective function of two resveratrol (trans-3,5,4'-trihydroxystilbene) glucosides against oxidative stress. J Pharmacol Exp Ther 344:124-32 (2013). Mouse . PubMed: 23042952
  • Gagou ME  et al. Suppression of Apoptosis by PIF1 Helicase in Human Tumor Cells. Cancer Res 71:4998-5008 (2011). Human . PubMed: 21616935
  • Aguzzi MS  et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer 9:84 (2010). ICC/IF ; Human . PubMed: 20412563
  • Pupure J  et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett 470:100-5 (2010). WB, IHC-P . PubMed: 20036318
  • Gagou ME  et al. Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Biol Cell 21:739-52 (2010). WB ; Human . PubMed: 20053681
  • Myers K  et al. ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet 5:e1000324 (2009). WB ; Human . PubMed: 19119425
  • Ottewell PD  et al. Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone. Mol Cancer Ther 8:2821-32 (2009). WB ; Human . PubMed: 19789217


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