Overview

  • Product name
    Anti-active Caspase 6 antibody
  • Description
    Rabbit polyclonal to active Caspase 6
  • Host species
    Rabbit
  • Specificity
    This antibody recognizes the large subunit (18 kDa) of the active caspase 6. The antibody does not recognize any other caspase.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human active Caspase 6. Synthetic peptide surrounding amino acids mapping to the C-terminus of the large fragment of Human Caspase-6.

  • General notes


    The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 30% Glycerol, 0.5% BSA, PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Primary antibody notes
    The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab2326 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml.

Target

References

This product has been referenced in:
  • Li X  et al. Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid Redox Signal 21:1675-92 (2014). Mouse . Read more (PubMed: 24483844) »
See 1 Publication for this product

Customer reviews and Q&As

1-3 of 3 Q&A

Answer

Thanks for your enquiry.

I am sorry but we do not have a western blot available for this antibody.

When you refer to Abcam's "policy regarding antibodies", I presume you mean a guarantee. We do have a guarantee which we refer to as the Abpromise. In general, it states we guarantee the antibody to perform as noted on the datasheet. If it does not, we encourage you to contact us within 6 months of receiving the antibody and we'll do our best to help troubleshoot any issues. However, if the antibody still does not perform as expected, we are happy to offer a replacement, credit or refund.

For complete information, please see the following link:

https://www.abcam.com/abpromise

I hope this is helpful. Please contact me again if you have any further questions.

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Question
Answer

This antibody reacts specifically to the large sub-unit (18 kDa) of the active caspase-6.

I hope this is helpful. Please contact me again if you have any further questions.

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Question
Answer

We have three caspase 6 antibodies, none have been tested in IHC.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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