This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute in sterile 18MOhm/cm water to not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Parathyroid hormone 1
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Involvement in disease
Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.