Active human TRIM5 gamma peptide (ab41839)

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Key features and details

  • Active: Yes
  • Suitable for: Blocking

Description

  • Product name

    Active human TRIM5 gamma peptide

  • Biological activity

    Blocking the activity of the TRIM5 gamma antibody (ab17203).

  • Animal free

    No

  • Nature

    Synthetic

    • Species

      Human

Specifications

Our Abpromise guarantee covers the use of ab41839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.1% BSA

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • RING finger protein 88
    • RNF88
    • TRIM5
    • TRIM5_HUMAN
    • Tripartite motif containing 5
    • Tripartite motif protein TRIM5
    • Tripartite motif-containing protein 5
    see all

  • Function

    Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.

  • Pathway

    Protein modification; protein ubiquitination.

  • Sequence similarities

    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.

  • Domain

    The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.

  • Post-translational
    modifications

    Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).

  • Cellular localization

    Cytoplasm > P-body. Cytoplasmic bodies.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab41839? Please let us know so that we can cite the reference in this datasheet.

ab41839 has not yet been referenced specifically in any publications.

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