Active human TRIM5 gamma peptide (ab41839)
- Datasheet
- References
- Protocols
Description
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Product name
Active human TRIM5 gamma peptide -
Biological activity
Blocking the activity of the TRIM5 gamma antibody (ab17203). -
Animal free
No -
Nature
Synthetic -
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Species
Human
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Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab41839 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking - Blocking peptide for Anti-TRIM5 gamma antibody (ab17203)
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSAThis product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
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Alternative names
- RING finger protein 88
- RNF88
- TRIM5
see all -
Function
Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity. -
Pathway
Protein modification; protein ubiquitination. -
Sequence similarities
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger. -
Domain
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. -
Post-translational
modificationsUbiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro). -
Cellular localization
Cytoplasm > P-body. Cytoplasmic bodies. - Information by UniProt
Datasheets and documents
References
ab41839 has not yet been referenced specifically in any publications.
